The Mechanism of Adjuvanticity of Aluminium-Containing Formulas

Author(s): Kaat Fierens, Mirjam Kool

Journal Name: Current Pharmaceutical Design

Volume 18 , Issue 16 , 2012


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Abstract:

Vaccinations have been given to people for at least 100 years of which 80 years formulated in adjuvants. Currently, aluminium- containing formulas and the oil-based substance called MF59 are the two adjuvants licensed for clinical use. Despite the massive use of aluminium adjuvant, its mechanism of action has been only recently addressed. In this review, we will discuss both the cellular and molecular mode of action of aluminium-containing adjuvants.

Keywords: Adjuvant, aluminium hydroxide, dendritic cell, NLRP3, Syk, uric acid and dsDNA

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Article Details

VOLUME: 18
ISSUE: 16
Year: 2012
Published on: 03 April, 2012
Page: [2305 - 2313]
Pages: 9
DOI: 10.2174/138161212800166004
Price: $65

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