The Potentials of Selected Therapeutic Targets for Inflammation: A Snapshot

Author(s): Sneha Nayadu, Ginpreet Kaur, Girish Gudi, Veeranjaneyulu Addepalli

Journal Name: Recent Patents on Inflammation & Allergy Drug Discovery

Volume 6 , Issue 2 , 2012

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Inflammation is a complex integrated host response to infection and injury. Inflammatory cells respond to foreign substances and inflammatory stimulus by producing various chemical bioactive mediators such as prostanoids, cytokines and chemokines. These mediators have complex, pleiotropic effects and interact with many cell types and cellular pathways to amplify the inflammatory response. Dysregulation of these processes can lead to acute and chronic inflammatory diseases necessitating pharmacological intervention to attenuate cellular inflammation pathways. This review focuses on new targets and alternative approaches to the development of novel therapeutics based on the endogenous chemicals mediators and the regulation of the associated cellular pathways that modulate inflammation leading its resolution and patents relevant to these targets.

Keywords: Adiponectin, ATP (adenosine triphosphate), chemokine, cyclooxygenase-2, heme oxygenase (HO)-1, NF-κB, PAR (protease-activated receptor, PPAR-γ, protectin, resolvin, ROS (reactive oxygen species)

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Article Details

Year: 2012
Page: [137 - 146]
Pages: 10
DOI: 10.2174/187221312800166840
Price: $65

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