Pharmacokinetics and In Vivo Fate of Drug Loaded Chitosan Nanoparticles++

Author(s): Xiawei Wei, Zhirong Zhang, Zhiyong Qian

Journal Name: Current Drug Metabolism

Volume 13 , Issue 4 , 2012

Become EABM
Become Reviewer
Call for Editor


Chitosan is a natural polysaccharide which is generally biodegradable, biocompatible and mucoadhesive, thus, attracting considerable interest of scientific researchers. The application of chitosan as nanocarriers for drug delivery thrived. And some of their pharmacokinetics and biodistribution profiles were studied, which are crucial to develop a promising drug delivery system. In this article, we will first give an introduction for the chitosan as drug delivery system, especially as nanoparticles. Then, we focus on pharmacokinetics studies of various chitosan nanoparticles both in vitro and in vivo. In a following part, we refer to researches on biodistribution properties of chitosan nanoparticles. Here we crucially discuss the in vivo fate of chitosan nanoparticles. And finally, toxicity issue is discussed and conclusions are drawn.

Keywords: Biodistribution, chitosan, delivery, in vivo, nanoparticles, pharmacokinetics

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2012
Published on: 02 April, 2012
Page: [364 - 371]
Pages: 8
DOI: 10.2174/138920012800166580
Price: $65

Article Metrics

PDF: 32