Pharmacokinetics and Disposition of Nanomedicine Using Biodegradable PEG/PCL Polymers as Drug Carriers

Author(s): YuJun Wang, MaLing Gou, ChangYang Gong, Cheng Wang, ZhiYong Qian, Yun Feng Lin, Feng Luo

Journal Name: Current Drug Metabolism

Volume 13 , Issue 4 , 2012

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Abstract:

Micelles assembled from amphiphilic poly(ethylene glycol)/poly(ε -caprolactone) (PEG/PCL) copolymers are promised as safe and effective drug delivery systems. They offer the potential to achieve high solubility of hydrophobic drugs, long blood circulation time and effective delivery to target organs. These advantages contribute to their application as vehicles of a broad variation of therapeutic compounds. In this review, we discussed the safety of the copolymers, release behavior of PEG/PCL micelles in vitro, and pharmacokinetic profiles referring to the optimized fate in vascular system and targeting biodistribution.

Keywords: PEG, PCL, micelles, biodegradation, release, long circulation, target

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Article Details

VOLUME: 13
ISSUE: 4
Year: 2012
Page: [338 - 353]
Pages: 16
DOI: 10.2174/138920012800166490
Price: $65

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