Title:Pharmacokinetics and Disposition of Nanomedicine Using Biodegradable PEG/PCL Polymers as Drug Carriers
VOLUME: 13 ISSUE: 4
Author(s):YuJun Wang, MaLing Gou, ChangYang Gong, Cheng Wang, ZhiYong Qian, Yun Feng Lin and Feng Luo
Affiliation:State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, PR China.
Keywords:PEG, PCL, micelles, biodegradation, release, long circulation, target
Abstract:Micelles assembled from amphiphilic poly(ethylene glycol)/poly(ε -caprolactone) (PEG/PCL) copolymers are promised as safe
and effective drug delivery systems. They offer the potential to achieve high solubility of hydrophobic drugs, long blood circulation time
and effective delivery to target organs. These advantages contribute to their application as vehicles of a broad variation of therapeutic
compounds. In this review, we discussed the safety of the copolymers, release behavior of PEG/PCL micelles in vitro, and pharmacokinetic
profiles referring to the optimized fate in vascular system and targeting biodistribution.
