Recent Advances and Patents for Nerve Scaffold Biomaterials and their Use for Local, Non-Viral Delivery of Growth Factors and Nucleic Acids

Author(s): Justin M. Saul, James B. Clarke

Journal Name: Recent Patents on Biomedical Engineering (Discontinued)

Volume 5 , Issue 1 , 2012


Injuries to the peripheral and central nervous system represent difficult physical challenges for those suffering from these injuries as well as a significant cost to the U.S. healthcare system. Treatment methods include electrical stimulation, improved rehabilitation techniques, cell therapies, and biomaterials. Biomaterial solutions to the challenges of nerve injury offer a potential long-term solution if used alone or in combination with other treatment modalities, and have therefore received considerable attention for product development. Controlled release of protein-based therapeutics such as growth factors is likely to be a critical design component to achieving long-term success with biomaterials. We consider the alternative approach of nucleic acid delivery through non-viral approaches as a means to achieve spatio-temporal control over growth factor delivery. We also describe promising aspects of non-viral delivery methods of antisense (e.g., siRNA) from biomaterials for nerve regeneration that could help to overcome the challenges of up-regulation of inhibitory molecules following injury.

Keywords: Controlled release, local delivery, biomedical devices, interfering RNA, gene delivery

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Article Details

Year: 2012
Published on: 27 March, 2012
Page: [74 - 82]
Pages: 9
DOI: 10.2174/1874764711205010074

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