Natural Products as Leads for Tuberculosis Drug Development

Author(s): Christine E. Salomon, Lori E. Schmidt

Journal Name: Current Topics in Medicinal Chemistry

Volume 12 , Issue 7 , 2012

Become EABM
Become Reviewer
Call for Editor


New therapeutics are urgently needed to combat the immense disease burden of tuberculosis and related mycobacterial diseases worldwide. Natural products continue to provide leads for the development of novel drugs to treat the rapidly growing numbers of patients with multi- and extensively-drug resistant tuberculosis. This review presents natural products and synthesized analogues with anti-mycobacterial activity published between 2006 through 2009. Structure activity relationships, synthetic analogues and newly reported activities of known compounds reported during this period are also included.

Keywords: Natural products, tuberculosis, drug development, mycobacterium tuberculosis, drug resistant tuberculosis, structure activity relationship

open access plus

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2012
Published on: 18 March, 2012
Page: [735 - 765]
Pages: 31
DOI: 10.2174/156802612799984526

Article Metrics

PDF: 109