Using Extracellular Matrix-Derived Peptides to Alter the Microenvironment for Myocardial Repair

Author(s): Shirley S. Mihardja, Randall J. Lee

Journal Name: Current Vascular Pharmacology

Volume 10 , Issue 3 , 2012

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Myocardial repair remains a major challenge for both cellular and tissue engineering approaches. Several studies have been conducted looking at utilizing extracellular matrix-based therapies to promote repair after a myocardial infarction. In this review, strategies for treating myocardial infarctions using extracellular matrix-derived peptides are discussed. Using an ischemia/reperfusion myocardial infarction rodent model, we showed that extracellular-matrix-derived peptides were able to induce angiogenesis and alter the negative remodeling seen after a myocardial infarction. This therapy opens up a potentially new non-invasive strategy for repairing damaged cardiac tissue.

Keywords: Extracellular matrix, myocardial infarction, tissue engineering, cardiac repair, angiogenesis

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Article Details

Year: 2012
Page: [342 - 346]
Pages: 5
DOI: 10.2174/157016112799959341
Price: $65

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