Anti-Oxidative Effect of Curcumin Against Tert-Butylhydroperoxide Induced Oxidative Stress in Human Erythrocytes

Author(s): Prabhakar Singh, Syed Ibrahim Rizvi

Journal Name: The Natural Products Journal

Volume 2 , Issue 1 , 2012

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Curcumin (diferuloylmethane, 1, 6-heptadiene-3, 5-5dione-1, 7-bis (4-hydroxy-3-methoxyphenyl)), a constituent of turmeric (curcuma longa), is traditionally used in various diseases. We report the strong anti-oxidative effect of curcumin on markers of oxidative stress in human erythrocytes subjected to in vitro oxidative stress by incubating with tert-butylhydroperoxide (t-BHP). Results show that curcumin protects erythrocyte lipid peroxidation (MDAMalondialdehyde) and decrease of glutathione (GSH) during oxidative stress. The quotient of MDA/GSH is high during stress however presence of curcumin (10-8 M-10-5 M) decreased the index (MDA/GSH) substantiating the antioxidant effect of curcumin in a model cell system. The effect of curcumin is dose-dependent with maximum effect at 10-5M. Since oxidative stress has been implicated in the pathogenesis of many diseases/conditions, a therapeutic role of curcumin is hypothesized.

Keywords: Antioxidant, curcumin, erythrocyte, glutathione, malondialdehyde, oxidative stress, Tert-Butylhydroperoxide, lipid peroxidation, free radical

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Article Details

Year: 2012
Published on: 01 March, 2012
Page: [69 - 73]
Pages: 5
DOI: 10.2174/2210315511202010069

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