One Pot Multi-Component Synthesis of N-Substituted Decahydroacridine- 1, 8-Diones Catalyzed by MoO3/SiO2 as an Efficient and Reusable Heterogeneous Catalyst

Title: One Pot Multi-Component Synthesis of N-Substituted Decahydroacridine- 1, 8-Diones Catalyzed by MoO3/SiO2 as an Efficient and Reusable Heterogeneous Catalyst

Volume: 1 Issue: 1

Author(s): Vijay S. Patil, Kamalakar P. Nandre, Mohan B. Kalyankar, Santosh V. Nalage, Namdev V. Ghule, Sidhanath V. Bhosale and Sheshanath V. Bhosale

Affiliation:

Keywords: N-Substituted decahydroacridine-1, 8-dione, MoO3/SiO2, solid acid catalyst, one pot multi-component, Heterogeneous Catalyst, organic synthesis, pharmaceutical chemistry, raw materials, non-toxic reagents, solvents, catalysts, medicinal chemistry, material science, antimalerial, anti-inflammatory

Abstract: A simple, efficient and ecofriendly one pot synthesis protocol has been developed for the synthesis of N-substituted decahydroacridine-1,8-diones by using an efficient and recyclable solid acidic silica supported MoO3/SiO2 catalyst from a condensation of aldehyde, amine and cyclic 1,3-diketone in THF. The reaction using MoO3/SiO2 catalyst was carried out under mild condition with very high yields up to 92%. The present approach of this methodology offers several advantages such as shorter reaction times, good yields, low cost, environmentally benign, milder reaction conditions, easy recovery of catalyst and reusability.

Cite this article as:

S. Patil Vijay, P. Nandre Kamalakar, B. Kalyankar Mohan, V. Nalage Santosh, V. Ghule Namdev, V. Bhosale Sidhanath and V. Bhosale Sheshanath, One Pot Multi-Component Synthesis of N-Substituted Decahydroacridine- 1, 8-Diones Catalyzed by MoO3/SiO2 as an Efficient and Reusable Heterogeneous Catalyst, Current Catalysis 2012; 1 (1) . https://dx.doi.org/10.2174/2211544711201010073