H6P2W12O62.24H2O Supported on Silica: A Powerful and Reusable Catalyst for the Synthesis of 4-Arylidene-2-Phenyl-5(4)-Oxazolones (Azlactones)

Title: H6P2W12O62.24H2O Supported on Silica: A Powerful and Reusable Catalyst for the Synthesis of 4-Arylidene-2-Phenyl-5(4)-Oxazolones (Azlactones)

Volume: 1 Issue: 1

Author(s): Diego M. Ruiz, Graciela T. Baronetti, Horacio J. Thomas and Gustavo P. Romanelli

Affiliation:

Keywords: Heterogeneous catalysis, Wells-Dawson heteropolyacid, Green Chemistry, 4-arylidene-2-phenyl-5(4)-oxazolones, Azlactones, chemistry, homogeneous, heteropolyacids, organic chemists, bioactive compounds, biological sciences, pharmaceutical science, asymmetric synthesis, amino acids

Abstract: A simple, efficient and ecofriendly one-pot synthesis protocol has been developed for the synthesis of 4- arylidene-2-phenyl-5(4)-oxazolones (azlactones) by using an efficient and recyclable solid acid silica-supported H6P2W18O62.24H2O catalyst from a condensation of aldehydes, hippuric acid and acetic anhydride in toluene. The reaction using 0.4WDSiO2 catalyst was carried out under mild conditions with very high yields of up to 89%-93%. The heterogeneous reaction conditions provided a very simple, environmentally friendly, clean, economical and selective protocol for the preparation of these compounds. The catalyst is easily recycled and reused without loss of the catalytic activity.

Cite this article as:

M. Ruiz Diego, T. Baronetti Graciela, J. Thomas Horacio and P. Romanelli Gustavo, H6P2W12O62.24H2O Supported on Silica: A Powerful and Reusable Catalyst for the Synthesis of 4-Arylidene-2-Phenyl-5(4)-Oxazolones (Azlactones), Current Catalysis 2012; 1 (1) . https://dx.doi.org/10.2174/2211544711201010067