Recent Advances Using Supercritical Fluid Techniques for Pulmonary Administration of Macromolecules via Dry Powder Formulations

Author(s): Iman M. Al-fagih, Fars K. Alanazi, Gillian A. Hutcheon, Imran Y. Saleem

Journal Name: Drug Delivery Letters

Volume 1 , Issue 2 , 2011

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Growing demands on a suitable formulation method that ensures the stability of the active compound coupled with the limitations of current methods (milling, lyophilization, spray drying, and freeze spray drying) has brought wide attention to supercritical fluid (SCF) technology. Advantages of using the SCF technology comprise its high abilities, adaptability in providing alternative processing methods, high compressibility and diffusivity of the supercritical fluid, capability as an alternative for conventional organic solvents, and the option to attain different processing parameters which would be otherwise difficult to conduct with traditional methods. This review proposes to present an up-to-date outlook on dry powder pulmonary formulations of macromolecules using SCF technology.

Keywords: Dry powder, super critical fluid, protein, microparticles, peptide, macromolecules, SCF, Anaemia, Encapsulation of Insulin, POWDER INHALATION, inhalation

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Article Details

Year: 2011
Page: [128 - 134]
Pages: 7
DOI: 10.2174/2210304x11101020128
Price: $25

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