Synthesis and Anti-tubercular Activities of Benzo[4,5]furo[2,3-c] Chromen -6-one Derivatives

Author(s): Noopur Srivastava, K. S. Anil Kumar, Sudhir Sinha, Ranjana Srivastava, D. K. Dikshit

Journal Name: Anti-Infective Agents
Formerly Anti-Infective Agents in Medicinal Chemistry

Volume 10 , Issue 1 , 2012

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Synthesis and in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Ra and H37Rv of a number of 3-hydroxy[2,3-c][1]benzopyran-6(H)-ones 1a-f and 3-Benzyl-8-hydroxy-1,2,3,4-tetrahydro-chromeno[3,4- c]pyridin-5-ones 8a-c has been reported. Few of the compounds exhibited anti–tubercular activity with MIC as low as 3.12 μg/ml in virulent and avirulent strains.

Keywords: BACTEC, Coumarin, MDR tuberculosis, pechman condensation, triarylmethanes, tuberculosis, BCG, Benzofurans, ANTI-TUBERCULAR ACTIVITY, DMAP

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Article Details

Year: 2012
Page: [6 - 14]
Pages: 9
DOI: 10.2174/2211362611201010006

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