Chaos and Gene expression: A Theoretical Approach

Author(s): Athanasios Tsatsaris, Dimitrios Triantaffylou, Antonios Baldoukas, George Tsiolis, Despina Perrea

Journal Name: Recent Patents on Biomedical Engineering (Discontinued)

Volume 4 , Issue 1 , 2011

Abstract:

Intoduction: The aim of the study was to investigate whether chaotic phenomena (chaos theory) affects the process of Gene Expression.

Methods: Modeling the genes X, Y and Z-which encode a certain protein P-a set of three first order differential equations has been developed and studied in phase-space (x,y,z).

Results: The elementary equilibrium points in three dimensional phase portrait analysis, include attractors, saddles and repellors.

Conclusions: Attractors indicate a stable equilibrium point which attenuates the production of the protein P, while the saddles and particularly the repellors correspond to an unstable dynamic system, which promotes either the production of a P-flaw protein or totally inhibits gene expression. Among other mechanisms-e.g. patents for gene treatment (US2007000515344) and modulation(US20040014083A1)-chaotic phenomena also seem to regulate in a particular way the DNA encoding , that calls for further theoretical and experimental research(e.g. cardiovascular disease, oncology).

Keywords: DNA, chaos, phase-space, gene expression, cardiovascular disease

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Article Details

VOLUME: 4
ISSUE: 1
Year: 2011
Page: [49 - 53]
Pages: 5
DOI: 10.2174/1874764711104010049

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