CD4C/HIVNef Tg mice express HIV-1 Nef in relevant target cells through the regulatory sequences of the human CD4 gene. These mice develop a severe disease showing many characteristics of human AIDS. A summary of the results obtained with these Tg mice is presented.
Keywords: HIV-1, Nef, mouse model, AIDS, SIV, HIVAN, CD4C/HIVNef, Transgene, Tg DC, AIDS-LIKE DISEASE
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