The CD4C/HIVNef Transgenic Model of AIDS

Author(s): Paul Jolicoeur

Journal Name: Current HIV Research

Volume 9 , Issue 7 , 2011

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Abstract:

CD4C/HIVNef Tg mice express HIV-1 Nef in relevant target cells through the regulatory sequences of the human CD4 gene. These mice develop a severe disease showing many characteristics of human AIDS. A summary of the results obtained with these Tg mice is presented.

Keywords: HIV-1, Nef, mouse model, AIDS, SIV, HIVAN, CD4C/HIVNef, Transgene, Tg DC, AIDS-LIKE DISEASE

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Article Details

VOLUME: 9
ISSUE: 7
Year: 2011
Page: [524 - 530]
Pages: 7
DOI: 10.2174/157016211798842062
Price: $65

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