Abstract
Iron is the most abundant chemical element on Earth but its most common oxidation state is Fe(III) which presents a very low solubility under physiological conditions. During evolution, micro-organisms have developed sound strategies to acquire iron from both the environment and superior organisms, including direct uptake of iron ions from exogenous iron/heme sources and the synthesis of specialized Fe(III) chelators called siderophores. The present review paper aims at presenting and discussing the latest achievements in siderophore isolation and production, as well as novel applications of these molecules in therapies against iron-related diseases and in vaccines, and their application as antimicrobial agents and biosensors.
Keywords: Antibacteria, antifungal, antimicrobial, biosensor, catecholate, chelation therapy, hydroxamate, iron chelation, iron homeostasis, iron overload, Neurodegenerative diseases, Pathogen competition, Pyoverdin, Siderophore, synthesis, vaccines
Recent Patents on Biotechnology
Title: Recent Achievements on Siderophore Production and Application
Volume: 5 Issue: 3
Author(s): Carla C.C.R. de Carvalho, Marco P.C. Marques and Pedro Fernandes
Affiliation:
Keywords: Antibacteria, antifungal, antimicrobial, biosensor, catecholate, chelation therapy, hydroxamate, iron chelation, iron homeostasis, iron overload, Neurodegenerative diseases, Pathogen competition, Pyoverdin, Siderophore, synthesis, vaccines
Abstract: Iron is the most abundant chemical element on Earth but its most common oxidation state is Fe(III) which presents a very low solubility under physiological conditions. During evolution, micro-organisms have developed sound strategies to acquire iron from both the environment and superior organisms, including direct uptake of iron ions from exogenous iron/heme sources and the synthesis of specialized Fe(III) chelators called siderophores. The present review paper aims at presenting and discussing the latest achievements in siderophore isolation and production, as well as novel applications of these molecules in therapies against iron-related diseases and in vaccines, and their application as antimicrobial agents and biosensors.
Export Options
About this article
Cite this article as:
C.C.R. de Carvalho Carla, P.C. Marques Marco and Fernandes Pedro, Recent Achievements on Siderophore Production and Application, Recent Patents on Biotechnology 2011; 5 (3) . https://dx.doi.org/10.2174/187220811797579114
DOI https://dx.doi.org/10.2174/187220811797579114 |
Print ISSN 1872-2083 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4012 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Insights in microRNAs Biology
Current Topics in Medicinal Chemistry Cardiovascular Aspect of Beta-Thalassaemia
Cardiovascular & Hematological Agents in Medicinal Chemistry Platelets and Vascular Risk: An Option for Treatment
Current Pharmaceutical Design α-Lipoic Acid Supplementation: A Tool for Obesity Therapy?
Current Pharmaceutical Design The Coronary Circulation in Arterial Hypertension
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Effect of Chronic Melatonin Administration on Several Physiological Parameters from Old Wistar Rats and Samp8 Mice
Current Aging Science Glycyrrhizic Acid Ameliorates Cognitive Impairment in a Rat Model of Vascular Dementia Associated with Oxidative Damage and Inhibition of Voltage-Gated Sodium Channels
CNS & Neurological Disorders - Drug Targets Brain Injury Associated with Widely Abused Amphetamines: Neuroinflammation, Neurogenesis and Blood-Brain Barrier
Current Drug Abuse Reviews Inflammatory Biomarkers in Chronic Kidney Disease: A Review
Recent Patents on Biomarkers Incremental Value of Two Dimensional Speckle Tracking Echocardiography in the Functional Assessment and Characterization of Subclinical Left Ventricular Dysfunction
Current Cardiology Reviews Neurological Complications of Anderson-Fabry Disease
Current Pharmaceutical Design MicroRNAs: A Critical Regulator and a Promising Therapeutic and Diagnostic Molecule for Diabetic Cardiomyopathy
Current Gene Therapy Pharmaceutical Measures to Prevent Doxorubicin-Induced Cardiotoxicity
Mini-Reviews in Medicinal Chemistry The Role of Transforming Growth Factor β1 in the Regulation of Blood Pressure
Current Hypertension Reviews Editorial (Thematic Issue: Endothelium: A Target for Therapeutic Intervention)
Current Vascular Pharmacology The Applications of Biomarkers in Early Clinical Drug Development to Improve Decision-Making Processes
Current Clinical Pharmacology Treating Cancer in Older and Oldest Old Patients
Current Pharmaceutical Design Beta-Blockers use for Hypertension in the Elderly
Cardiovascular & Hematological Agents in Medicinal Chemistry Role of the Dopamine Transporter in the Action of Psychostimulants, Nicotine, and Other Drugs of Abuse
CNS & Neurological Disorders - Drug Targets The Oxygen Therapy
Current Medicinal Chemistry