Dietary Flavonoids: Molecular Mechanisms of Action as Anti- Inflammatory Agents

Author(s): Laura Marzocchella, Massimo Fantini, Monica Benvenuto, Laura Masuelli, Ilaria Tresoldi, Andrea Modesti, Roberto Bei

Journal Name: Recent Patents on Inflammation & Allergy Drug Discovery
Continued as Recent Advances in Inflammation & Allergy Drug Discovery

Volume 5 , Issue 3 , 2011


Flavonoids are a large group of polyphenolic compounds, which are ubiquitously expressed in plants. They are grouped according to their chemical structure and function into flavonols, flavones, flavan-3-ols, anthocyanins, flavanones and isoflavones. Many of flavonoids are found in fruits, vegetables and beverages. Flavonoids have been demonstrated to have advantageous effects on human health because their anti-allergic, anti-inflammatory, anti-platelet aggregation, antitumor and anti-oxidant behavior. This report reviews the current knowledge on the molecular mechanisms of action of flavonoids as anti-inflammatory agents and also discusses the relevant patents.

Keywords: Bioavailability, flavonoids, fruit, inflammation, Flavonols, Flavones, Anthocyanins, pro-inflammatory cytokines, NF-kB activation, Mitogen-Activated-Protein Kinases (MAPKs) signaling

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Article Details

Year: 2011
Page: [200 - 220]
Pages: 21
DOI: 10.2174/187221311797264937
Price: $65

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