Alpha-particle therapy has received increased attention during the last few years because of the development of new targeting constructs and new labeling techniques and the availability of suitable α-particle – emitting radionuclides. This work provides an overview of methods that have been used in clinical trials in estimating the absorbed dose to tumors and healthy tissue in patients following such α-particle therapy. Similarities and differences compared to conventional therapies using β¯-particle emitters are presented. The specific challenges of establishing accurate dosimetry for α- particles in the individual patient are also discussed, as is the effect that improved patient-specific dosimetry might have on the overall efficacy of this type of therapy.
Keywords: Alpha-particles, clinical trials, dosimetry, radionuclide therapy, regulators, (MTA, PATIENT PHARMACOKINETICS, PATIENT DOSIMETRY, Gamma Counters and Probes, Quantitative Imaging
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