Targeted Alpha Therapy with 213Bi

Author(s): Alfred Morgenstern, Frank Bruchertseifer, Christos Apostolidis

Journal Name: Current Radiopharmaceuticals

Volume 4 , Issue 4 , 2011

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The potential of targeted therapy with the alpha emitter 213Bi has been successfully demonstrated in a large number of preclinical studies and several clinical trials have provided evidence for its feasibility, safety and therapeutic efficacy. This review describes methods for the production of 225Ac and 225Ac/213Bi radionuclide generators, gives an overview of selected preclinical studies and summarizes the current clinical experience with 213Bi.

Keywords: Targeted alpha therapy, alpha emitter, actinium-225, bismuth-213, preclinical studies, clinical application, Alpha emitting radionuclides, RADIONUCLIDE GENERATORS, radiolabeled peptide, SPECT

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Article Details

Year: 2011
Page: [295 - 305]
Pages: 11
DOI: 10.2174/1874471011104040295
Price: $65

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PDF: 19