Bioengineering RNA Silencing Across the Life Kingdoms

Author(s): R. Alvarez-Fernandez, S. Lopez-Gomollon, A. F. Lopez-Martinez, F. E. Nicolas

Journal Name: Recent Patents on Biotechnology

Volume 5 , Issue 2 , 2011

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Abstract:

RNA silencing negatively regulates gene expression at transcriptional and posttranscriptional levels, guided by small RNA molecules. It modulates core regulatory pathways across the eukaryotes, such as developmental processes or stress responses. The widespread existence of this phenomenon and the key pathways regulated have led to the development of a new technology based on the modification of gene expression, which has been applied successfully in different areas such as medicine or agriculture. Here we review the most important patents related to RNA silencing across the life kingdoms, including biotechnological applications into medicine, crop science and bioengineering.

Keywords: Chlamydomonas, disease therapy, fungi, gene therapy, microRNA, patent, plant biotechnology, RNA silencing, sRNA, post-transcriptional gene silencing in plants, lymphoblastic leukaemia, anti-miRNA oligonucleotides (AMOs), Kaposi, ’, s sarcoma-associated herpesvirus (KSHV), respiratory syncytial virus (RSV), parainfluenza virus (PIV)

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Article Details

VOLUME: 5
ISSUE: 2
Year: 2011
Page: [118 - 146]
Pages: 29
DOI: 10.2174/187220811796365680
Price: $65

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