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Current HIV Research

Editor-in-Chief

ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

A RhoA-Derived Peptide Inhibits Human Immunodeficiency Virus-1 Entry In Vitro

Author(s): Maciej Maselko, Casey Ward and Manoj Pastey

Volume 9, Issue 1, 2011

Page: [1 - 5] Pages: 5

DOI: 10.2174/157016211794582605

Price: $65

Abstract

RhoA-derived peptides have been shown to have antiviral activity against both human respiratory syncytial virus and human parainfluenza virus-3. The present study investigates the toxicity, anti-HIV-1 activity and mechanism of action of a RhoA-derived peptide (RhoA 77-95). The efficacy of this peptide was compared to a scrambled peptide of the same amino acid composition and Enfuvirtide, a HIV entry inhibitor. Our data show that this RhoA-derived peptide is a non-toxic and effective inhibitor of a CXCR4 tropic strain of HIV-1. We also demonstrate that the mechanism of entry inhibition is likely mediated by polyanionic properties and is dependent on the dimerization of peptides.

Keywords: Antiviral, HIV-1, Peptides, RhoA

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