Microglia Phenotype Diversity

Author(s): M. Olah, K. Biber, J. Vinet, H. W.G.M. Boddeke

Journal Name: CNS & Neurological Disorders - Drug Targets
(Formerly Current Drug Targets - CNS & Neurological Disorders)

Volume 10 , Issue 1 , 2011

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Microglia, the tissue macrophages of the brain, have under healthy conditions a resting phenotype that is characterized by a ramified morphology. With their fine processes microglia are continuously scanning their environment. Upon any homeostatic disturbance microglia rapidly change their phenotype and contribute to processes including inflammation, tissue remodeling, and neurogenesis. In this review, we will address functional phenotypes of microglia in diverse brain regions and phenotypes associated with neuroinflammation, neurogenesis, brain tumor homeostasis, and aging.

Keywords: Microglia, aging, gliomas, white matter, grey matter, inflammation, MHC II, TREM2b, LCA, fibronectin, vitronectin, neurohypophysis, amyotrophic lateral, Alzheimer's disease, encephalomyelitis, EAE, prostaglandin, TGF-1, stroke, cyclooxygenase-2, CD86, HLA-DR, activation and complement, astrocytomas, metalloprotease, glioblastomas, Parkinson's disease

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Article Details

Year: 2011
Page: [108 - 118]
Pages: 11
DOI: 10.2174/187152711794488575

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