Airways inflammation in asthma is triggered and maintained by CD4+ (Th2) cells which are activated by IL-2 and stimulate the eosinophilic inflammation, IgE secretion and mucus hyperproduction. Current anti-inflammatory therapies include inhaled corticosteroids, and leukotriene modifiers but they are not universally effective. IL-2 pathway inhibition might represent a potent anti-inflammatory therapy in asthma given the cytokine early role in the asthma complex inflammatory cascade and daclizumab which is a IL-2R blocker currently used as an immunsupressor in organ transplantation might be a potential asthma therapy. This is a review on the pathogenic role of IL-2, on the therapeutic potential of daclizumab and on its related patents.
Keywords: CD25, subunit-IL-2 receptor, CD4+ activation, daclizumab, asthma
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Published on: 01 March, 2012
Page: [214 - 221]