Immunophenotype of Vitamin D Receptor Polymorphism Associated to Risk of HIV-1 Infection and Rate of Disease Progression

Author(s): Carmen Torres, Manuel Sanchez-de-la-Torre, Carelia Garcia-Moruja, Antonio Jose Carrero, Maria del Monte Trujillo, Joan Fibla, Antonio Caruz

Journal Name: Current HIV Research

Volume 8 , Issue 6 , 2010

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Vitamin-D-receptor (VDR) mediates immunomodulatory effects of vitamin-VD3 (VD3). The VDRrs1544410_ GG polymorphism has been associated with delayed progression rates to AIDS and resistance to HIV-1 infection. The aim of the present study was to investigate differences in VD3 mediated effects on rs1544410 genotyped dendritic cells (DCs) and macrophages (MDM), key cells involved in HIV-1 infection. Immature DCs exhibited lower bactin- normalized VDR mRNA expression in rs1544410_GG compared to cells with a rs1544410_AA genotype. VD3 response on cell differentiation markers (CD14 inhibition and CD209 induction) was two-fold higher in rs1544410_AA (CD209, p=0.012; CD14, p=0.02). HIV-1-LTR reporter gene activity in MDM was boosted by VD3 ; however, the effect was up to 50% higher in rs1544410_AA. We conclude that the rs1544410_AA association with progression to AIDS and resistance to HIV-1 appears to be linked to an enhanced response to VD3.

Keywords: Vitamin-D-receptor, rs1544410, dendritic cells, HIV-1, CD209, CD14, LTR

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Article Details

Year: 2010
Page: [487 - 492]
Pages: 6
DOI: 10.2174/157016210793499330
Price: $65

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