Abstract
HIV-1 has resulted in a devastating AIDS pandemic. An effective HIV/AIDS vaccine that can be used to either, prevent HIV infection, control infection or prevent progression of the disease to AIDS is needed. In this review we discuss the use of Mycobacterium bovis BCG, the tuberculosis vaccine, as a vaccine vector for an HIV vaccine. Numerous features make BCG an attractive vehicle to deliver HIV antigens. It has a good safety profile, elicits long-lasting cellular immune responses and in addition manufacturing costs are affordable, a necessary consideration for developing countries. In this review we discuss the numerous factors that influence generation of a genetically stable recombinant BCG vaccine for HIV.
Keywords: Recombinant BCG, Mycobacterium bovis BCG, HIV, vaccine vector
Current HIV Research
Title: Recombinant Mycobacterium bovis BCG as an HIV Vaccine Vector
Volume: 8 Issue: 4
Author(s): Rosamund Chapman, Gerald Chege, Enid Shephard, Helen Stutz and Anna-Lise Williamson
Affiliation:
Keywords: Recombinant BCG, Mycobacterium bovis BCG, HIV, vaccine vector
Abstract: HIV-1 has resulted in a devastating AIDS pandemic. An effective HIV/AIDS vaccine that can be used to either, prevent HIV infection, control infection or prevent progression of the disease to AIDS is needed. In this review we discuss the use of Mycobacterium bovis BCG, the tuberculosis vaccine, as a vaccine vector for an HIV vaccine. Numerous features make BCG an attractive vehicle to deliver HIV antigens. It has a good safety profile, elicits long-lasting cellular immune responses and in addition manufacturing costs are affordable, a necessary consideration for developing countries. In this review we discuss the numerous factors that influence generation of a genetically stable recombinant BCG vaccine for HIV.
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Cite this article as:
Chapman Rosamund, Chege Gerald, Shephard Enid, Stutz Helen and Williamson Anna-Lise, Recombinant Mycobacterium bovis BCG as an HIV Vaccine Vector, Current HIV Research 2010; 8 (4) . https://dx.doi.org/10.2174/157016210791208686
DOI https://dx.doi.org/10.2174/157016210791208686 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
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Management of HIV: Management of HIV: old challenges and new needs
The aim of this thematic issue is to provide the most recent updates regarding the effective management of HIV infection. Antiretroviral therapy (ART) has significantly decreased HIV-related mortality, leading to an enhancement in the quality of life and life expectancy for people living with HIV (PLWH). Despite the numerous advancements ...read more
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