Targeting Tumor Proteasome with Traditional Chinese Medicine

Author(s): Huanjie Yang, Jinbao Liu, Q. Ping Dou

Journal Name: Current Drug Discovery Technologies

Volume 7 , Issue 1 , 2010

Become EABM
Become Reviewer


The proteasome is a multicatalytic protease complex whose activity is required for the growth of normal or tumor cells. It has been shown that human cancer cells are more sensitive to proteasome inhibition than normal cells, indicating that the proteasome could be a target of chemotherapy. Studies suggest that traditional Chinese medicine (TCM) is an effective approach for cancer treatment. Here we reviewed several TCMs for their potential in treatment of cancer. This short review focuses mainly on the TCMs that potentially target the tumor cellular proteasome and NF-κB pathway whose activation is dependent on the proteasome activity.

Keywords: Proteasome inhibitors, natural products, medicinal compounds, cancer, prevention, treatment

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2010
Page: [46 - 53]
Pages: 8
DOI: 10.2174/157016310791162785

Article Metrics

PDF: 45