Title: Toxicokinetic Interaction Between Quetiapine and Antiretroviral Therapy Following Quetiapine Overdose
VOLUME: 4 ISSUE: 1
Author(s):P. Hantson, V. Di Fazio and P. Wallemacq
Affiliation:Department of Intensive Care, Cliniques St-Luc, Avenue Hippocrate, 10, 1200 Brussels, Belgium.
Keywords:Quetiapine, overdose, half life, antiretroviral therapy, CYP3A4
Abstract: A 47-year-old woman ingested an overdose of 8000 mg quetiapine. The treatment had been initiated 3 weeks before. The current medications were lamuvidine, ritonavir, atazanavir and tenofovir for an HIV infection. The patient presented a deep coma and sustained hypotension as main complications. The toxicokinetic data revealed a markedly prolonged elimination half-life for quetiapine (62.4 hours) and the relationship with antiretroviral therapy is discussed.
