Phosphotyrosine Phosphatases in Cancer Diagnostic and Treatment

Author(s): Maria M. Tiscornia, Mario A. Riera, Maria A. Lorenzati, Pedro D. Zapata

Journal Name: Recent Patents on DNA & Gene Sequences
Continued as Recent Advances in DNA & Gene Sequences

Volume 4 , Issue 1 , 2010


The activation of proteins by post-translational modification represents an important cellular mechanism for regulating most aspects of biological organization and control, including growth, development, homeostasis, and cellular communication. The complexity of protein modification includes phosphorylation and dephosphorylation, on proteins of different signaling pathways corresponding to growth, development, disease states, and aging. Current patents in phosphotyrosine phosphatases signaling pathway are focusing in diagnosis, prognosis and treatment. Many, new diagnosis techniques detect changes in mRNA expression with microarray technologies and others introduced specific antibodies for detection proteins changes, introducing to Biomedicine at Transcriptomic and Proteomic era. Many recent invent development alternative therapy with antibodies and inhibitors to PTPs that demonstrate the need to deepen understanding of the molecular mechanisms involved in the development of cancer.

Keywords: Phosphotyrosine phosphatases, signaling pathway, diagnosis and treatment, cancer

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2010
Page: [46 - 51]
Pages: 6
DOI: 10.2174/187221510790410804

Article Metrics

PDF: 18