Topical Use of Sucralfate in Epithelial Wound Healing: Clinical Evidence and Molecular Mechanisms of Action

Author(s): Laura Masuelli, Giovanni Tumino, Mario Turriziani, Andrea Modesti, Roberto Bei

Journal Name: Recent Patents on Inflammation & Allergy Drug Discovery
Continued as Recent Advances in Inflammation & Allergy Drug Discovery

Volume 4 , Issue 1 , 2010


Sucralfate is a basic aluminium salt of sucrose octasulphate which was orally employed for prevention and treatment of several gastrointestinal diseases including gastroesophageal reflux, gastric and duodenal ulcer. Recent studies have employed sucralfate as a topical drug for the healing of several types of epithelial wounds such as ulcers, inflammatory dermatitis, mucositis and burn wounds. Epithelial wound healing is a well orchestrated process involving hemostasis, inflammatory reaction, cell proliferation and tissue remodeling which leads to granulation tissue development and filling of the wound space. This report will review clinical evidence on the use of topical sucralfate for the management of epithelial lesions and deal with the current knowledge on the molecular mechanisms of action of this compound towards the epithelial wound healing process and will also discuss relevant patents.

Keywords: Sucralfate, topical, epithelial wound, healing, growth factors, inflammation

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Article Details

Year: 2010
Page: [25 - 36]
Pages: 12
DOI: 10.2174/187221310789895649

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PDF: 102