Racing of the Biological Pacemaker

Author(s): Han-Gang Yu

Journal Name: Recent Patents on DNA & Gene Sequences (Discontinued)

Volume 3 , Issue 3 , 2009


Over the past decade, rapid progress in the molecular studies of cardiac ion channels and stem cells biology has led to efforts to create a biological pacemaker to supplement the widely-used electronic pacemaker. This review focuses on the main concepts of cardiac pacemaker activities in different heart regions and the patented approaches to design a working biological pacemaker. The gene-based and cell-based approaches to meet the requirements of a working biological pacemaker are reviewed. Possible future development and precautions for creation of an effective biological pacemaker superior to the electronic counterpart are discussed.

Keywords: Cardiac pacemaker activity, biological pacemaker, HCN pacemaker channels, Kir2.1 potassium channels, inward current, outward current, gene transfer, stem cell, ventricular rate control

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Article Details

Year: 2009
Page: [193 - 200]
Pages: 8
DOI: 10.2174/187221509789318423
Price: $58

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