Abstract
Prevalence of obesity and bronchial asthma is increasing in industrialized countries. Several studies have suggested a relationship between these disorders. Evidence comes from studies with animal models as well as epidemiologic observations. Moreover, pulmonary function parameters, genetic and hormonal factors support the hypothesis that obesity and asthma are linked. Given the enormous economic impact effective and efficient treatment strategies for both diseases are important. The present review will describe patents and recent developments in drugs directed against obesity and asthma. Potential therapeutic targets include the ORL-1 receptor, the LPA receptor, the VEGF receptor, cannaboid receptor, T cells, and protein kinases.
Keywords: Asthma, cannaboid receptor, LPA receptor, obesity, ORL-1 receptor, protein kinase, T cell, VEGF receptor
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
Title: Obesity and Asthma
Volume: 3 Issue: 3
Author(s): Hans-Peter Hauber and Michael Wegmann
Affiliation:
Keywords: Asthma, cannaboid receptor, LPA receptor, obesity, ORL-1 receptor, protein kinase, T cell, VEGF receptor
Abstract: Prevalence of obesity and bronchial asthma is increasing in industrialized countries. Several studies have suggested a relationship between these disorders. Evidence comes from studies with animal models as well as epidemiologic observations. Moreover, pulmonary function parameters, genetic and hormonal factors support the hypothesis that obesity and asthma are linked. Given the enormous economic impact effective and efficient treatment strategies for both diseases are important. The present review will describe patents and recent developments in drugs directed against obesity and asthma. Potential therapeutic targets include the ORL-1 receptor, the LPA receptor, the VEGF receptor, cannaboid receptor, T cells, and protein kinases.
Export Options
About this article
Cite this article as:
Hauber Hans-Peter and Wegmann Michael, Obesity and Asthma, Recent Patents on Endocrine, Metabolic & Immune Drug Discovery 2009; 3 (3) . https://dx.doi.org/10.2174/187221409789104773
DOI https://dx.doi.org/10.2174/187221409789104773 |
Print ISSN 1872-2148 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3334 |
Related Articles
-
Importance of Fibroblasts-Myofibroblasts in Asthma-Induced Airway Remodeling
Recent Patents on Inflammation & Allergy Drug Discovery Liverworts-Potential Source of Medicinal Compounds
Current Pharmaceutical Design Chest X-ray in Sarcoidosis: The Association of Age, Gender, and Ethnicity with Different Radiological Findings
Current Respiratory Medicine Reviews Alpha-1-Antitrypsin Deficiency and Mechanisms of Liver Disease
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Mediterranean Diet and Longevity
Current Nutrition & Food Science Hapten Recognition by T Cells: A Functional and Molecular View
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Study of Convolvulus pluricaulis for Antioxidant and Anticonvulsant Activity
Central Nervous System Agents in Medicinal Chemistry Patent Review
Combinatorial Chemistry & High Throughput Screening On the Cellular and Molecular Regulatory Transcriptional Mechanisms and Responsive Putative Pathways to Inflammatory Oxidative Stress Revisited: Current Immunological Breakthroughs and Views at a Glance
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Meet Our Editorial Board Member
Current Organic Synthesis Meet Our Regional Editor
Applied Clinical Research, Clinical Trials and Regulatory Affairs An Overview on Global Trends in Nanotechnological Approaches for Alzheimer Therapy
Current Drug Metabolism Cold Virus Fusion or Stopping Fusion Cold – Inhibitors of the Human Respiratory Syncytial Virus F Protein
Recent Patents on Anti-Infective Drug Discovery Emerging Nanonisation Technologies: Tailoring Crystalline Versus Amorphous Nanomaterials
Current Topics in Medicinal Chemistry Peptide-based Vaccines in the Treatment of Specific Allergy
Current Drug Targets - Inflammation & Allergy Novel Drug-Induced Pulmonary Complications in Cancer Patients You Can Save Life!
Current Respiratory Medicine Reviews Exhaled Nitric Oxide in COPD
Current Respiratory Medicine Reviews Hypersensitivity Reactions to Last Generation Chimeric, Umanized and Human Recombinant Monoclonal Antibodies for Therapeutic Use
Current Pharmaceutical Design Reactive Oxygen Species in Pathogenesis of Atherosclerosis
Current Pharmaceutical Design Effects of Exercise on Anxiety and Depression Disorders: Review of Meta- Analyses and Neurobiological Mechanisms
CNS & Neurological Disorders - Drug Targets