Applications of Supercritical Fluid Chromatography-Tandem Mass Spectrometry in Pharmaceuticals

Author(s): Maria Espinosa Bosch, Antonin Jesus Ruiz Sanchez, Fuensanta Sanchez Rojas, Catalina Bosch Ojeda

Journal Name: Current Drug Discovery Technologies

Volume 6 , Issue 3 , 2009

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Abstract:

Supercritical fluid chromatography (SFC) is a fully mature technique and can readily be coupled to mass spectrometers relatively easily. In the last years, supercritical fluid chromatography coupled with mass spectrometry (SFCMS) has had a great advance in productivity, due to increase in reliability and robustness of both SFC and MS systems, the need to push drug discovery faster, and as a potential solution to old problems unsolved and new problems yet to be encountered. This article will illustrate the role of SFC-MS analysis in drug discovery process.

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Article Details

VOLUME: 6
ISSUE: 3
Year: 2009
Page: [214 - 229]
Pages: 16
DOI: 10.2174/157016309789054942
Price: $65

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