Title: Applications of Supercritical Fluid Chromatography-Tandem Mass Spectrometry in Pharmaceuticals
VOLUME: 6 ISSUE: 3
Author(s):Maria Espinosa Bosch, Antonin Jesus Ruiz Sanchez, Fuensanta Sanchez Rojas and Catalina Bosch Ojeda
Affiliation:Department of Analytical Chemistry, Faculty of Sciences, University of Malaga, 29071, Malaga, Spain.
Abstract: Supercritical fluid chromatography (SFC) is a fully mature technique and can readily be coupled to mass spectrometers relatively easily. In the last years, supercritical fluid chromatography coupled with mass spectrometry (SFCMS) has had a great advance in productivity, due to increase in reliability and robustness of both SFC and MS systems, the need to push drug discovery faster, and as a potential solution to old problems unsolved and new problems yet to be encountered. This article will illustrate the role of SFC-MS analysis in drug discovery process.
