Evaluation of Angiogenesis with the Expression of VEGF-C and CD34 in Human Colon Cancer

Author(s): Ana Maria Inda, Marcela Nilda Garcia, Laura Beatriz Andrini, Adriana Laura Garcia, Ayelen Fernandez Blanco, Cecilia Cristina Furnus, Susana Mercedes Galletti, Javier Brandoni, Jorge Guillermo Martinez, Guillermo Daniel Prat, Ana Lia Errecalde

Journal Name: Current Chemical Biology

Volume 3 , Issue 3 , 2009


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Abstract:

Background: The most potent angiogenic factor is the vascular endothelial growth factor (VEGF), and CD34 is an endothelial antigen that has been used to highlight the microvasculature vessel density (MVD) as a direct marker of the degree of neoangiogenesis. In the present study we report that VEGF expression and its relationship with MVD, in poorly and well differentiated colon adenocarcinoma, in order to consider the possibility of using the correlation between both antibodies as a prognostic factor. Materials and Methods: Tumor sections were stained by immunohistochemistry for CD34 and VEGF. Results: The mean of VEGF and CD34 did not show any significant differences between both types of tumors. Conclusion: The conventional factors taken into consideration were not significantly related to the angiogenic factors examined, so we could affirm that the correlation of both markers could be useful as prognostic factor.

Keywords: Colon cancer, VEGF, CD34, angiogenesis, colon, adenocarcinoma

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Article Details

VOLUME: 3
ISSUE: 3
Year: 2009
Published on: 01 March, 2012
Page: [302 - 305]
Pages: 4
DOI: 10.2174/2212796810903030302
Price: $25

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