Inhibition of Human Aromatase by Myosmine

Title: Inhibition of Human Aromatase by Myosmine

Volume: 3 Issue: 2

Author(s): Irene L. Doering and Elmar Richter

Affiliation:

Keywords: CYP19, cytochrome P450, human aromatase, myosmine, nicotine

Abstract: Myosmine, a minor tobacco alkaloid widely occurring in food products of plant and animal origin, inhibits the conversion of testosterone to estradiol by human aromatase (IC50: 33±2 μM) sevenfold more potent than nicotine (IC50: 223±10 μM) and may have implications for sexual hormone homoeostasis.

Cite this article as:

Doering L. Irene and Richter Elmar, Inhibition of Human Aromatase by Myosmine, Drug Metabolism Letters 2009; 3 (2) . https://dx.doi.org/10.2174/187231209788654045