Inhibition of Human Aromatase by Myosmine

Author(s): Irene L. Doering, Elmar Richter

Journal Name: Drug Metabolism Letters

Volume 3 , Issue 2 , 2009

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Myosmine, a minor tobacco alkaloid widely occurring in food products of plant and animal origin, inhibits the conversion of testosterone to estradiol by human aromatase (IC50: 33±2 μM) sevenfold more potent than nicotine (IC50: 223±10 μM) and may have implications for sexual hormone homoeostasis.

Keywords: CYP19, cytochrome P450, human aromatase, myosmine, nicotine

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Article Details

Year: 2009
Page: [83 - 86]
Pages: 4
DOI: 10.2174/187231209788654045
Price: $65

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