Esterase Activities in the Blood, Liver and Intestine of Several Preclinical Species and Humans

Author(s): Loren M. Berry, Lance Wollenberg, Zhiyang Zhao.

Journal Name: Drug Metabolism Letters

Volume 3 , Issue 2 , 2009

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Species and tissue differences in the activity of three major classes of esterases, carboxylesterase (CE), butyrylcholinesterase (BChE) and paraoxonase (PON), were studied. Substantial species differences in activity of these esterases were observed between the mouse, rat, dog monkey and human. Such species differences must be considered when using these preclinical species to optimize the pharmacokinetic properties of ester compounds intended for human use.

Keywords: Carboxylesterase, cholinesterase, paraoxonase, species difference

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Article Details

Year: 2009
Page: [70 - 77]
Pages: 8
DOI: 10.2174/187231209788654081
Price: $58

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PDF: 131