Recent Patents on Genes and Gene Sequences Useful for Developing Breast Cancer Detection Systems

Author(s): Divya Singh, Rekha Chaturvedi

Journal Name: Recent Patents on DNA & Gene Sequences
Continued as Recent Advances in DNA & Gene Sequences

Volume 3 , Issue 2 , 2009


Breast cancer is the most prevalent disease and second leading cause of death among women in many countries. Mutations and consequent DNA damage in several genes such as oncogenes and tumour suppressor genes have been implicated with abnormal behavior of somatic cells, resulting into malignant growth termed cancer. DNA damage/changes in chromosomal DNA and failure of DNA repair mechanism are important factors for cancer causation. Aberrant behavior of cells leading to uncontrolled proliferation causing cancer is attributable to amplicon formation, large deletions in some genes, mutations, and recombination breakpoints etc. which cause aberrant gene expression. Several patented genes found to be associated with breast cancer, have been discussed, such as BRCA1, BRCA2, DAP kinase, MYH, BCSGs, BCW 2 and Id-2 etc. Several of the genes/markers associated with breast cancer can be considered as appropriate candidates for developing early detection systems/protocols for breast cancer.

Keywords: Breast cancer, cell proliferation, mutations, altered gene expression, high risk, cancer diagnosis, genetic testing

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Article Details

Year: 2009
Published on: 01 March, 2012
Page: [139 - 147]
Pages: 9
DOI: 10.2174/187221509788654188
Price: $65

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