Novel Application of Plasma Treatment for Pharmaceutical and Biomedical Engineering

Author(s): Masayuki Kuzuya, Yasushi Sasai, Shin-ichi Kondo, Yukinori Yamauchi

Journal Name: Current Drug Discovery Technologies

Volume 6 , Issue 2 , 2009


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Abstract:

The nature of plasma-induced surface radicals formed on a variety of organic polymers has been studied by electron spin resonance (ESR), making it possible to provide a sound basis for future experimental design of polymer surface processing using plasma treatment. On the basis of the findings from such studies, several novel bio-applications in the field of drug- and biomedical- engineering have been developed. Applications for drug engineering include the preparation of reservoir-type drug delivery system (DDS) of sustained- and delayed-release, and floating drug delivery system (FDDS) possessing gastric retention capabilities, followed by preparation of “Patient-Tailored DDS”. Furthermore, the preparation of composite powders applicable to matrix-type DDS was developed by making a mechanical application to the surface radical-containing polymer powders with drug powders. In applications for biomedical engineering, the novel method to introduce the durable surface hydrophilicity and lubricity on hydrophobic biomedical polymers was developed by plasma-assisted immobilization of carboxyl group-containing polymer on the polymer substrate. The surfaces thus prepared were further used for the covalent immobilization of oligo-nucleotides (DNA) onto the polymer surfaces applicable to constructing DNA diagnosis system, and also plasma-assisted preparation of functionalized chemo-embolic agent of vinyl alcohol-sodium acrylate copolymer (PVA- PAANa).

Keywords: Plasma treatment, electron spin resonance (ESR), surface radical, drug delivery system (DDS), patient-tailored DDS, composite powder, DNA-chip, chemo-embolic agent

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Article Details

VOLUME: 6
ISSUE: 2
Year: 2009
Page: [135 - 150]
Pages: 16
DOI: 10.2174/157016309788488311
Price: $65

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