Abstract
After the infusion of HIV-1 virus into a host cell, RNA is reverse transcribed to dsDNA, which persists intracellular to the infected cell in a variety of forms. Numerous in-house assays have been developed for the quantification of the different cellular HIV-1 DNA forms; these implement conventional or real-time PCR methodology. In this review we discuss recent findings about the longitudinal monitoring of cell-associated HIV-1 DNA in naïve and pre-treated patients, as a marker for clinical progression, treatment initiation and long-term success of HAART. These findings underline the importance of monitoring HIV-1 DNA in clinical practice, in addition to HIV-RNA and CD4+ T Cell counts, for the better assessment of HIV-treatment and disease progression. The lack of a standardized real-time PCR assay is major impediment to more wide-spread HIV-1 DNA monitoring.
Keywords: HIV-1 DNA, Real-time PCR, Prognostic marker, Disease progression
Current HIV Research
Title: The Role of HIV-1 DNA as an Additional Marker of HIV-1 Infection
Volume: 7 Issue: 3
Author(s): Apostolos Beloukas, Dimitrios Paraskevis, Mina Psichogiou and Angelos Hatzakis
Affiliation:
Keywords: HIV-1 DNA, Real-time PCR, Prognostic marker, Disease progression
Abstract: After the infusion of HIV-1 virus into a host cell, RNA is reverse transcribed to dsDNA, which persists intracellular to the infected cell in a variety of forms. Numerous in-house assays have been developed for the quantification of the different cellular HIV-1 DNA forms; these implement conventional or real-time PCR methodology. In this review we discuss recent findings about the longitudinal monitoring of cell-associated HIV-1 DNA in naïve and pre-treated patients, as a marker for clinical progression, treatment initiation and long-term success of HAART. These findings underline the importance of monitoring HIV-1 DNA in clinical practice, in addition to HIV-RNA and CD4+ T Cell counts, for the better assessment of HIV-treatment and disease progression. The lack of a standardized real-time PCR assay is major impediment to more wide-spread HIV-1 DNA monitoring.
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Cite this article as:
Beloukas Apostolos, Paraskevis Dimitrios, Psichogiou Mina and Hatzakis Angelos, The Role of HIV-1 DNA as an Additional Marker of HIV-1 Infection, Current HIV Research 2009; 7 (3) . https://dx.doi.org/10.2174/157016209788348001
DOI https://dx.doi.org/10.2174/157016209788348001 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
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