Higher Placental Anti-Inflammatory IL-10 Cytokine Expression in HIV-1 Infected Women Receiving Longer Zidovudine Prophylaxis Associated with Nevirapine

Author(s): Sakorn Pornprasert, Jean-Yves Mary, Albert Faye, Pranee Leechanachai, Aram Limtrakul, Sungwal Rugpao, Pannee Sirivatanapa, Vorapin Gomuthbutra, Wanmanee Matanasaravoot, Sophie Le Coeur, Marc Lallemant, Francoise Barre-Sinoussi, Elisabeth Menu, Nicole Ngo-Giang-Huong

Journal Name: Current HIV Research
HIV and Viral Immune Diseases

Volume 7 , Issue 2 , 2009


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Abstract:

Placental cytokine balance may be critical for the control of mother-to-child transmission (MTCT) of HIV. We assessed whether the type and duration of antiretrovirals used for prevention of HIV-1-MTCT modified the inflammatory cytokine profile. We investigated the levels of cytokine expression in the placentas of 61 HIV-1-infected women who received zidovudine (ZDV) plus single dose nevirapine (SD-NVP) or ZDV only for prevention of MTCT. Placentas of 38 HIV-1-uninfected women were included as controls. All placentas were obtained after vaginal delivery. Levels of mRNA and cytokine expression were quantified using real-time PCR and ELISA, respectively, in placental explants and 24-hour culture supernatants and analyzed in relation to the womens characteristics and the type and duration of antiretroviral prophylaxis. HIV-1-infected and uninfected women did not show any differences in the expression of placental cytokine secretion except for a trend toward lower TNF-α mRNA levels in HIV-1-infected women. Within the HIV-1-infected group, women who were exposed to a long duration of ZDV ( > 72 days) or received SD-NVP less than 5h prior to delivery, more frequently expressed detectable levels of IL-10 in their placentas (32% versus 7% (p = 0.01) and 32% versus 5% (p = 0.02), respectively). No infant was found to be HIV-1-infected. Our results showed a normalization of the placental cytokine balance in HIV-1-infected women receiving antiretroviral prophylaxis. Furthermore, the type and duration of antiretroviral prophylaxis have an impact on the placental anti-inflammatory IL-10 expression level, which may contribute to controlling HIV replication at the placental level, thus reducing MTCT of HIV-1.

Keywords: HIV-1, placenta, antiretroviral prophylaxis, zidovudine and nevirapine, IL-10 cytokine, mother-to-child transmission

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Article Details

VOLUME: 7
ISSUE: 2
Year: 2009
Published on: 01 March, 2012
Page: [211 - 217]
Pages: 7
DOI: 10.2174/157016209787581472
Price: $65

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