Selective Gene Amplification for High-Throughput Sequencing

Author(s): Ting Ni, Han Wu, Shen Song, Mark Jelley, Jun Zhu

Journal Name: Recent Patents on DNA & Gene Sequences
Continued as Recent Advances in DNA & Gene Sequences

Volume 3 , Issue 1 , 2009


With tremendous progress in next generation sequencing technologies, it has become possible to perform genomic sequencing in a highly cost-effective manner. However, the human genome remains too complex to be routinely re-sequenced. Thus, selective gene amplification is often employed to target a subset of genomic regions (such as a set of disease-related genes) for deep sequencing analysis. Herein, we briefly review patents that can enrich target genomic regions of interest to harness the power of NextGen sequencing technology for basic and translational biomedical research.

Keywords: Gene-collector, selector, megaPlex PCR, multiplex exon capture, sequence-capture array, selective amplification, nextGen sequencing, deep sequencing

promotion: free to download

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2009
Page: [29 - 38]
Pages: 10
DOI: 10.2174/187221509787236183

Article Metrics

PDF: 22