For the last two decades, intensive research has been focused on developing reinforced polymers with incorporation of nanometric fillers. Amongst the different types of nanofillers, those based on layered silicates (commonly known as clays), have been most widely investigated. Dispersing clay sheets on a nanoscopic scale (so-called exfoliation) indeed allows materials with enhanced thermal, mechanical, rheological, flame retardancy and barrier properties to be produced. However, the nanocomposite performances are strongly dependent upon the extent of clay exfoliation. In order to enhance the compatibility between the pristine clay, hydrophilic, and the polymer, hydrophobic, and to achieve a good delamination of the nanolayers, an organo-modification of the clay is most usually necessary. This mini-review will provide an outline of patenting activity in the field of manufacturing organoclays through ionic exchange. The variety of organic modifiers and the diverse processing techniques will be detailed, aiming to extract the most relevant organoclays for successful nanocomposite formation at industrial scale.