Synthesis, Characterisation, Anti-Microbial Activity and Docking Studies of Novel Dispiro- Oxindolopyrrolidines

Author(s): Adukamparai R. Suresh Babu, Raghavachary Raghunathan, Kuppamuthu Kumaresan, Nanjian Raaman

Journal Name: Current Chemical Biology

Volume 3 , Issue 1 , 2009

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2-arylidene-1,3-indanediones undergo a regioselective 1,3-dipolar cycloaddition reaction with the azomethine ylide derived from isatin and proline to give a rare class of novel complex dispirooxindolopyrrolizidines in better yield under microwave irradiation than classical heating. X-ray crystal structure analysis of one of the product confirms the structure and regiochemical outcome of the cycloaddition reaction. Anti-microbial activity studies were carried out with all the newly synthesized dispiro-oxindolopyrrolizidines.

Keywords: 1,3-dipole/kwd, >, azomethine ylide, oxindole, pyrrolizidines, antimicrobial activity

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Article Details

Year: 2009
Page: [112 - 123]
Pages: 12
DOI: 10.2174/2212796810903010112

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