Targeting Endogenous Mu- and Delta-Opioid Receptor Systems for the Treatment of Drug Addiction

Author(s): T. S. Shippenberg, A. LeFevour, V. I. Chefer.

Journal Name: CNS & Neurological Disorders - Drug Targets
(Formerly Current Drug Targets - CNS & Neurological Disorders)

Volume 7 , Issue 5 , 2008

Become EABM
Become Reviewer


Drug addiction is a chronic, relapsing disorder that is characterized by a compulsion to take drug regardless of the adverse consequences that may ensue. Although the involvement of mesoaccumbal dopamine neurons in the initiation of drug abuse is well-established, neuroadaptations within the limbic cortical- striatopallidal circuit that occur as a consequence of repeated drug use are thought to lead to the behavioral dysregulation that characterizes addiction. Opioid receptors and their endogenous ligands are enriched in brain regions comprising this system and are, thus, strategically located to modulate neurotransmission therein. This article will review data suggesting an important role of mu-opioid receptor (MOPr) and delta opioid receptor (DOPr) systems in mediating the rewarding effects of several classes of abused drugs and that aberrant activity of these opioid systems may not only contribute to the behavioral dysregulation that characterizes addiction but to individual differences in addiction vulnerability.

Keywords: Opioid receptors, drug self-administration, enkephalin, endorphin, cocaine, ethanol, morphine

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2008
Page: [442 - 453]
Pages: 12
DOI: 10.2174/187152708786927813
Price: $65

Article Metrics

PDF: 10