Advances in Drug Discovery to Assess Cholinergic Neurotransmission: A Systematic Review

Author(s): Vitor F. Ferreira, David R. da Rocha, Katia G. Lima Araujo, Wilson C. Santos

Journal Name: Current Drug Discovery Technologies

Volume 5 , Issue 3 , 2008

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Neurotransmission is essential to physiological processes of cellular communication. The search for new molecules that may influence neurotransmission systems is an open field with possible impact on several pathophysiological conditions or diseases: Alzheimers disease, Parkinsonism and myasthenia gravis, etc. The present review describes the most important aspects of cholinergic neurotransmission, as well as natural and synthetic compounds that, as clinical or experimental drugs, are able to influence this transmission. The pharmacological effects of substances that bind to muscarinic or nicotinic cholinergic receptors, along with their corresponding affinities will also be presented.

Keywords: Cholinergic neurotransmission, cholinergic receptors, carbohydrates

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Article Details

Year: 2008
Published on: 01 March, 2012
Page: [236 - 249]
Pages: 14
DOI: 10.2174/157016308785739848
Price: $65

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