Interactions of β - and Hydroxypropyl-β-Cyclodextrin with Some Purine Alkaloids:Thermodynamic Study

Author(s): Irina V. Terekhova

Journal Name: Current Drug Discovery Technologies

Volume 5 , Issue 2 , 2008

Become EABM
Become Reviewer
Call for Editor


The effect of native and hydroxypropylated β-cyclodextrin on the solubility and activity of some purine alkaloids was examined. For this purpose, the solubility of purine alkaloids in pure water and in aqueous solutions of mentioned β-cyclodextrins was determined at 298.15 K. Stability constants of inclusion complexes and their stoichiometry were obtained from solubility diagrams. Enthalpic characteristics of interactions occurring between β-cyclodextrins and purine alkaloids in aqueous solution were calculated from the direct calorimetric measurements. It was found, that β-cyclodextrin forms with purine alkaloids weak complexes which are stabilized only by the entropy term. Due to very low complexing affinity of both β-cyclodextrins to studied purine alkaloids their solubilizing effect is insignificant. The influence of structure of purine alkaloids and β-cyclodextrin on the thermodynamic parameters of interaction was discussed.

Keywords: Cyclodextrin, xanthines, solubility, calorimetry, thermodynamics of interactions

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2008
Page: [168 - 172]
Pages: 5
DOI: 10.2174/157016308784746201
Price: $65

Article Metrics

PDF: 3