Gene Targeting for Chromosome Engineering Applications in Eukaryotic Cells

Author(s): Leszek A. Lyznik, Virginia Dress

Journal Name: Recent Patents on Biotechnology

Volume 2 , Issue 2 , 2008

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As biotechnology advances, there is an increasing need to develop new technologies that may assist in more precise genetic engineering manipulations. Whether a placement of single genes in the proper chromosomal context, stacking a number of genes in the same chromosomal locus, rearrangement of existing chromosomal elements, or a global reconfiguration of the chromosomal structures is contemplated, the new genetic tools being developed provide technical capabilities to achieve goals that were only theoretical not long ago. We use examples of recent patent literature (issued patents and published patent applications) to illustrate trends in this fast advancing area of genetic technology. If one wants to engage in the development and utilization of such technologies, the complexity of genetic manipulations requires a careful evaluation and navigation across the legal/patent landscape of chromosomal modification/remodeling. While this review is mostly focused on the basic laboratory tools of chromosomal manipulations, their specific applications for biomedical, pharmaceutical, or agricultural purposes may deserve an additional compilation.

Keywords: Gene targeting, zinc fingers, meganuclease

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Article Details

Year: 2008
Page: [94 - 106]
Pages: 13
DOI: 10.2174/187220808784619720
Price: $65

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