HIV Nef: Role in Pathogenesis and Viral Fitness

Author(s): Kevin K. Arien, Bruno Verhasselt

Journal Name: Current HIV Research

Volume 6 , Issue 3 , 2008

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Conserved in all primate lentivirus genomes, Nef promotes viral replication and infectivity, influences the trafficking of a large number of surface receptors and interferes with TCR signalling, consequently modulating T-cell activation. In vivo observations with Long Term Non-Progressors harbouring a Nef-defective HIV and vaccination studies with Nef-deleted SIV in Rhesus macaques have shown a prominent role for Nef in lentiviral pathogenesis. Here we review the functions of Nef involved in viral replication and infectivity and speculate on a possible role for Nef in HIV fitness.

Keywords: HIV, nef, fitness, pathogenesis, replication

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Article Details

Year: 2008
Page: [200 - 208]
Pages: 9
DOI: 10.2174/157016208784325001
Price: $65

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PDF: 15