Abstract
The advent of the post genomics era coupled with advances in proteomics presents unprecedented opportunities for expedited discovery of microbial targets for subsequent development of novel modalities for management of infectious diseases. Here, we review a new application of proteomics called Proteomics-based Expression Library Screening (PELS). This functional proteomics tool permits rapid definition of comprehensive microbial immunoproteomes (microbial proteins expressed in vivo that elicit and interact with the host humoral immune response), a subset of which have excellent potential as diagnostic, drug and vaccine targets. PELS is a platform technology that is applicable to any sequenced pathogen. It offers several advantages over existing methods for global identification of immunogenic microbial proteins, and is both a rapid alternative and an adjunct to emerging protein antigen array/chip technologies.
Keywords: Proteomics, pathogen specific-markers, immunogenic, diagnostic, drug-target, vaccine
Current Proteomics
Title: Proteomics-Based Expression Library Screening (PELS): A Functional Proteomics Tool for Rapid Discovery of Immunogenic Pathogen-Specific Markers of Host Infection
Volume: 5 Issue: 1
Author(s): Indira T. Kudva and Manohar John
Affiliation:
Keywords: Proteomics, pathogen specific-markers, immunogenic, diagnostic, drug-target, vaccine
Abstract: The advent of the post genomics era coupled with advances in proteomics presents unprecedented opportunities for expedited discovery of microbial targets for subsequent development of novel modalities for management of infectious diseases. Here, we review a new application of proteomics called Proteomics-based Expression Library Screening (PELS). This functional proteomics tool permits rapid definition of comprehensive microbial immunoproteomes (microbial proteins expressed in vivo that elicit and interact with the host humoral immune response), a subset of which have excellent potential as diagnostic, drug and vaccine targets. PELS is a platform technology that is applicable to any sequenced pathogen. It offers several advantages over existing methods for global identification of immunogenic microbial proteins, and is both a rapid alternative and an adjunct to emerging protein antigen array/chip technologies.
Export Options
About this article
Cite this article as:
Kudva T. Indira and John Manohar, Proteomics-Based Expression Library Screening (PELS): A Functional Proteomics Tool for Rapid Discovery of Immunogenic Pathogen-Specific Markers of Host Infection, Current Proteomics 2008; 5 (1) . https://dx.doi.org/10.2174/157016408783955137
DOI https://dx.doi.org/10.2174/157016408783955137 |
Print ISSN 1570-1646 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6247 |
Call for Papers in Thematic Issues
Mass spectrometry data acquisition and analysis for proteomics
The Thematic Issue on "Mass spectrometry data acquisition and analysis for proteomics" aims to explore the latest advancements and challenges in the field of proteomics through the lens of mass spectrometry. Proteomics, the large-scale study of proteins and their functions, plays a crucial role in understanding various biological processes and ...read more
Peptides: State-of-Art and Commercialisation Hurdles
The Editors of the Current Proteomics (CP) journal are highly privileged to welcome scientists to submit their scientific research and review articles to be considered for publication in the upcoming thematic issue. The topics should cover various aspects of peptides in regard to their synthetic methodologies, formulation approaches, pharmacological challenges, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Novel Insights Into Lp(a) Physiology and Pathogenicity: More Questions Than Answers?
Cardiovascular & Hematological Disorders-Drug Targets Allosteric Regulators of the Proteasome: Potential Drugs and a Novel Approach for Drug Design
Current Medicinal Chemistry Current Status and Future Prospects of C1 Domain Ligands as Drug Candidates
Current Topics in Medicinal Chemistry Overview of the Genetic Basis and Epigenetic Mechanisms that Contribute to FASD Pathobiology
Current Topics in Medicinal Chemistry Recent Advances in the Membrane Receptor Initiated Vitamin D Signaling of Calcium and Phosphate Transport Across Intestinal and Kidney Epithelia
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Insights into the Platelet Releasate
Current Pharmaceutical Design Iron Chelators for the Treatment of Cancer
Current Medicinal Chemistry From Alpha to Omega with Aβ: Targeting the Multiple Molecular Appearances of the Pathogenic Peptide in Alzheimers Disease
Current Medicinal Chemistry Goal Directed Fluid Therapy
Current Pharmaceutical Design Vascular Oxidative Stress: A Key Factor in the Development of Hypertension Associated with Ethanol Consumption
Current Hypertension Reviews Non-steroidal Anti-Inflammatory Drugs and Melanoma
Current Pharmaceutical Design Anti-Inflammatory Drug Targeting in Asthma. Should Inhaled Corticosteroids Reach the Small Airways?
Current Drug Therapy Genetically Engineered Stem Cells for Therapeutic Gene Delivery
Current Gene Therapy Limitations of Current Antiretroviral Agents and Opportunities for Development
Current Pharmaceutical Design Developments on Drug Delivery Systems for the Treatment of Mycobacterial Infections
Current Topics in Medicinal Chemistry Potential Applications of Induced Pluripotent Stem Cells (iPSCs) in Hepatology Research
Current Stem Cell Research & Therapy CB1 Cannabinoid Receptors and their Associated Proteins
Current Medicinal Chemistry Is Fibroblast Growth Factor Receptor 4 a Suitable Target of Cancer Therapy?
Current Pharmaceutical Design Gene Therapy for Chronic Granulomatous Disease: Current Status and Future Perspectives
Current Gene Therapy Evidence-Based Management of Infertile Couples with Repeated Implantation Failure Following IVF
Current Women`s Health Reviews