Investigations Into the Drug-Drug Interaction Potential of Tapentadol in Human Liver Microsomes and Fresh Human Hepatocytes

Author(s): Christa Kneip, Rolf Terlinden, Horst Beier, Genfu Chen

Journal Name: Drug Metabolism Letters

Volume 2 , Issue 1 , 2008

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The new analgesic tapentadol was evaluated for induction and inhibition of several cytochrome P450 enzymes in vitro, and protein binding was assessed. It was concluded that no clinically relevant drug – drug interactions are likely to occur through either mechanism.

Keywords: protein binding, CYP isoforms, Hepatocytes, omeprazole, glucuronidation

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Article Details

Year: 2008
Published on: 01 March, 2012
Page: [67 - 75]
Pages: 9
DOI: 10.2174/187231208783478434

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