Abstract
The new analgesic tapentadol was evaluated for induction and inhibition of several cytochrome P450 enzymes in vitro, and protein binding was assessed. It was concluded that no clinically relevant drug – drug interactions are likely to occur through either mechanism.
Keywords: protein binding, CYP isoforms, Hepatocytes, omeprazole, glucuronidation
Drug Metabolism Letters
Title: Investigations Into the Drug-Drug Interaction Potential of Tapentadol in Human Liver Microsomes and Fresh Human Hepatocytes
Volume: 2 Issue: 1
Author(s): Christa Kneip, Rolf Terlinden, Horst Beier and Genfu Chen
Affiliation:
Keywords: protein binding, CYP isoforms, Hepatocytes, omeprazole, glucuronidation
Abstract: The new analgesic tapentadol was evaluated for induction and inhibition of several cytochrome P450 enzymes in vitro, and protein binding was assessed. It was concluded that no clinically relevant drug – drug interactions are likely to occur through either mechanism.
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Cite this article as:
Kneip Christa, Terlinden Rolf, Beier Horst and Chen Genfu, Investigations Into the Drug-Drug Interaction Potential of Tapentadol in Human Liver Microsomes and Fresh Human Hepatocytes, Drug Metabolism Letters 2008; 2 (1) . https://dx.doi.org/10.2174/187231208783478434
DOI https://dx.doi.org/10.2174/187231208783478434 |
Print ISSN 1872-3128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-0758 |
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